HAN LAB@NJUCM
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Ji Yu
Email: yuji@njucm.edu.cn
research direction:
Synthesize semiconductor conjugated polymers and small molecules for biological information sensing
Organic-inorganic hybrid materials for biological applications
Design and synthesis of conjugated polymers and small molecule nanoparticles with near-infrared absorption or near-infrared second window fluorescence emission for integrated diagnosis and treatment of living organisms
Design and synthesis of multimodal imaging probes for biological information sensing
Self-assembly of nanomaterials
Drug delivery
Personal profile:
Ji Yu, PhD, is a lecturer in the School of Integrative Medicine, School of Medicine, Nanjing University of Chinese Medicine, and a teacher in the Department of Biochemistry and Molecular Biology. Mainly undertake the teaching work of "Medical Chemistry", "Biochemistry and Molecular Biology" and other undergraduate courses.
In December 2019, he graduated from the Fan Quli group led by Academician Huang Wei of Nanjing University of Posts and Telecommunications. In March 2020, he joined Nanjing University of Chinese Medicine School of Integrative Medicine. In February 2021, he joined Professor Han Xin’s micro-nano manufacturing and Translational medicine cross-team laboratory. Will operate various large instruments. For example, hemispherical array photoacoustic scanner (Endra Nexus128). Photoacoustic imaging is a composite biomedical imaging mode, which is developed based on the photoacoustic effect. Compared with the advantages of fluorescence imaging, ultrasound imaging, X-ray and PET imaging, it has attracted wide attention; the two-window in vivo imaging instrument, Princeton Instruments 2D OMA-V 1.7. Near-infrared zone II (NIR-II, 1.0-1.7 um) fluorescence imaging technology has the advantages of high resolution and deep penetration. It is an emerging non-radiation and damage-free detection technology in the field of molecular imaging. Synthesize organic materials (polymers, two-photon materials, endogenous polymers, etc.) and various inorganic materials (such as gold nanoparticles, gold nanorods, mesoporous silicon, manganese dioxide, upconversion nanoparticles, calcium phosphide, etc.) ), and good at combining organic and inorganic materials for application.
Presided over the Provincial Youth Science Foundation and participated in a number of general projects of the National Natural Science Foundation of China. Published in international mainstream SCI academic journals such as Biomaterials, Nanoscale, J. Mater. Chem. B as the first author or co-author, and authorized 1 Chinese invention patent.
Five representative research papers in recent years:
1. Y. Ji, F. Lu, W. Hu, H. Zhao, Y. Tang, B. Liu, X. Hu, X. Li, X. Lu, Q. Fan, and W. Huang; "Tandem Activated Photodynamic and Chemotherapy: Using pH-Sensitive Nanosystems to Realize Different Tumour Distributions of Photosensitizer/Prodrug for Amplified Combination Therapy”; Biomaterials, 2019, 219, 119393.
2. L. Chen#, Y. Ji#, X. Hu, C. Cui, H. Liu, Y. Tang, B. Qi, Y. Niu, X. Hu*, A. Yu*, Q. Fan* ; "Cationic poly-L-lysine- encapsulated melanin nanoparticles as efficient photoacoustic agents targeting to glycosaminoglycans for the early diagnosis of articular cartilage degeneration in osteoarthritis"; Nanoscale, 2018, 10, 13471-13484.
3. J. Yan#, Y. Ji#, P. Zhang, X. Lu, Q. Fan, D. Pan, R. Yang, Y. Xu, L. Wang, L. Zhang and M. Yang, “Melanin nanoparticles as an endogenous agent for efficient iron overload therapy”; J. Mater. Chem. B, 2016,4, 7233-7240.
4. Y. Ji, W. Hu, F. Lu, W. Deng, H. Zhao, X. Lu, Q. Fan* and W. Huang; “Conjugated Polyelectrolyte Brush as Template Synthesis of Different-Sized Gold Nanoparticles for Photoacoustic Imaging- Guided Photothermal Therapy”; Inorganic Chemistry Communications, 2020, 111, 107460.
5. Y. Tang, Y. Li, X. Hu, H. Zhao, Y. Ji, L. Chen, W. Hu, W. Zhang, X. Li, X. Lu, W. Huang and Q. Fan*; " Dual Lock-and-Key"-Controlled Nanoprobes for Ultrahigh Specific Fluorescence Imaging in the Second Near-Infrared Window"; Adv. Mater., 2018