Yang Kaiyong

Personal profile:

Yang Kaiyong (Email: yangky003@njucm.edu.cn), Ph.D., lecturer at Nanjing University of Chinese Medicine School of Medicine and School of Integrative Medicine. Obtained a doctorate in pharmacy from Nanjing University in 2020, and joined Nanjing University of Chinese Medicine School of Medicine and School of Integrative Medicine in August of the same year.

Mainly engaged in the research of tumor immunology and molecular pharmacology. In the course of research in tumor immunology, the applicant confirmed that the activation of Angiotensin II and its type I receptor AGTR1 promotes the formation of an immunosuppressive microenvironment in non-small cell lung cancer, causing tumor cell immune escape, which can weaken the effectiveness of tumor immunotherapy. Effect, this work was published in Int Immunopharmacol  In the magazine. In the course of research in the direction of molecular pharmacology, the applicant found that ursolic acid can be specifically used for the treatment of non-small cell lung cancer with EGFR T790M mutation. This work was published in Br J Pharmacol  In the magazine. So far, the applicant has been published in the international SCI journals Int Immunopharmacol., Br J Pharmacol., Metab Brain Dis., Biochem Pharmacol., Oncol Lett  Published 5 papers; among them, the first author was in Br J Pharmacol  And Int Immunopharmacol  The papers published on were approved by J Hematol Oncol., Int J Mol Sci  And Br J Pharmacol  Cited by famous international academic journals.

Mainly responsible for the teaching of "Biochemistry and Molecular Biology" undergraduate course experiment; as a member of the Chinese Chemical Society.

Five representative research papers in recent years:

1. Yang K, Zhou J, Chen Y, Chen Y, Chen L, Zhang P, Ma L, Jiang Z, Bian J, Yin W. Angiotensin II contributes to intratumoral immunosuppressionvia induction of PD-L1 expression in non-small cell lung carcinoma. Int Immunopharmacol. 2020 Jul;84:106507. doi: 10.1016/j.intimp.2020.106507.

2. Yang K, Chen Y, Zhou J, Ma L, Shan Y, Cheng X, Wang Y, Zhang Z, Ji X, Chen L, Dai H, Zhu B, Li C, Tao Z, Hu X, Yin W. Ursolic acid promotes apoptosis and mediates transcriptional suppression of CT45A2 gene expression in non-small-cell lung carcinoma harbouring EGFR T790M mutations. Br J Pharmacol. 2019 Dec;176(24):4609-4624. doi: 10.1111/bph.14793.