Han Xin

Research direction: microfluidic chip technology, gene editing and multifunctional bio-nanomaterials. Xin Han, Ph.D., professor of Nanjing University of Chinese Medicine School of Integrative Medicine, doctoral supervisor, director of the Department of Biochemistry and Molecular Biology, Biochemistry and Leader of the Department of Molecular Biology, Distinguished Professor of Jiangsu Province, and core member of the Jiangsu “Double Innovation Project” team project. He received his Ph.D. degree in biochemistry and molecular biology from Sun Yat-sen University in 2013. He has worked as a visiting scholar, postdoctoral fellow and associate researcher at the MD Anderson Cancer Center of the University of Texas, and the Houston Methodist Hospital Research Institute affiliated to Cornell University. Joined Nanjing University of Chinese Medicine School of Medicine and School of Integrative Medicine in October 2018.
Presided over a number of national, provincial and ministerial projects such as the National Natural Science Foundation of China, the Natural Science Funded Talent Project for Distinguished Professors of Jiangsu Province, and the Nanjing Science and Technology Innovation Project for Overseas Students. Mainly engaged in the research of microfluidic chip technology and translational medicine, gene editing and multifunctional bio-nano materials. Published more than 10 international mainstream SCI academic papers such as Science Advances, Angewandte Chemie, Small, Advanced Healthcare Materials, Aging Cell, Analytical Chemistry as the first author or corresponding author, with the highest number of citations of more than 200, and was written by Science as the title "CRISPR-Cas9 delivery by microfluidics" is a special report on the research highlights, which has been reported by well-known professional media and news publications at home and abroad such as Science News, and has been reported by Nature Reviews Drug Discovery, Chemical Reviews, Materials Today, Nano Today, Advanced Drug Delivery Reviews, Nature Biomedical Engineering, Science Advances, PNAS, Blood, Angewandte Chemie, ACS Nano and other internationally renowned academic journals cited and gave positive reviews; as co-authors in Science Advances, JACS, PNAS, Angewandte Chemie, Molecular Cell, Nucleic Acids Research, Cell Reports, Genes & Development, Lab on a Chip, Analytical Chemistry, ACS Applied Materials & Interfaces, Advanced Healthcare Materials and other international mainstream SCI journals have published more than 30 academic papers, with a total of more than 1,200 citations; authorized 1 US invention patent.
Mainly undertake the teaching of "Biochemistry and Molecular Biology", "Medical Cell Biology" and other undergraduate courses, and "Advanced Pathology" and other postgraduate courses. Served as a member of the first committee of the Nanjing University of Chinese Medicine Science and Technology Association, a member of the first youth committee of the Pharmaceutical Analysis Technology Branch of the Chinese Medical Biotechnology Association, a member of the Chinese Society of Biochemistry and Molecular Biology, and a member of the Chinese Chemical Society. He has been invited to give academic reports at international conferences such as Lab-on-a-Chip & Microfluidics World Congress many times, and served as an international academic journal such as Small, Lab on a Chip, Advanced Healthcare Materials, Analytical Chemistry, etc. Reviewers.
Five representative research papers in recent years
[1]Chen C.#, Ma Y.#, Du S., Wu Y., Shen P., Yan T., Li X., Song Y.*, Zha Z.*,  Han X*. (2021). Controlled CRISPR-Cas9 Ribonucleoprotein Delivery for Sensitized Photothermal Therapy.  Small. e2101155. doi: 10.1002/smll.202101155. (Front Cover)
[2]Li X.#, Pan Y.#, Chen C., Gao Y., Liu X., Yang K., Luan X., Zhou D., Zeng F.,  Han X.*, Song Y*. (2021). Hypoxia-Responsive Gene Editing to Reduce Tumor Thermal Tolerance for Mild-Photothermal Therapy.  Angewandte Chemie International Edition. doi: 10.1002/anie.202107036.
[3]Shao, N.#,  Han, X.#, Song, Y., Zhang, P., and Qin, L*. (2019). CRISPR-Cas12a Coupled with Platinum Nanoreporter for Visual Quantification of SNVs on a Volumetric Bar-Chart Chip.  Analytical Chemistry  91, 12384-12391.
[4]Han, X.#, Liu, Z.#, Zhao, L., Wang, F., Yu, Y., Yang, J., Chen, R., and Qin, L*. (2016). Microfluidic Cell Deformability Assay for Rapid and Efficient Kinase Screening with the CRISPR-Cas9 System.  Angewandte Chemie International Edition  55, 8561-8565.
[5]Han, X., Liu, Z., Jo, MC, Zhang, K., Li, Y., Zeng, Z., Li, N., Zu, Y., and Qin, L*. (2015 ). CRISPR-Cas9 delivery to hard-to-transfect cells via membrane deformation.  Science Advances  1, e1500454.